Hypovitaminosis D can result in low bone mass. The prevalence of hypovitaminosis D has public health implications, especially where data are lacking. Since diet and sunlight are the two souces of vitamin D, the results obtained in one geographical region may not be universally applicable. The aim of this study is to characterize the 25-hydroxyvitamin D(3) (25-OHD(3)) serum level and its relationship to bone metabolism in a group of postmenopausal Iranian women.Serum levels of 25-hydroxyvitamin D(3) (25-OHD(3)) and bone mineral density (BMD) were determined in 186 randomly ambulatory selected, early postmenopausal women referred to the Bone Densitometry Center,Tehran, Iran. The relationship between them was also assessed. 25-OHD(3) levels were measured using high-performance liquid chromatography. BMD was measured with dual-energy X-ray absorptiometry of the lumbar spine and proximal femur regions. 25-OHD(3) levels ranged from 3.8 to 64.0 ng/mL (mean +/- SD: 17.1 +/- 11.3). Fifty-two subjects (36%) were vitamin D-deficient (<12 ng/mL). In the lumbar spine (L2-4) BMD measurements, 56 individuals (38%) were normal (T score > -1), 52 (36%) were osteopenic (T < or = -1 to >-2.5), and 38 (26%) were osteoporotic (T < -2.5). In the hip (total) BMD measurements, 82 caess (56.1%) were normal, 62 (42.5%) were osteopenic, and 2 (1.4%) was osteoporotic. There was a significant correlation between spine BMD (Z score) and 25-OHD(3) (r = 0.23, p < 0.05), but that was not significant for hip BMD. It was prudent to say that vitamin D deficiency was evident in early postmenopausal Iranian women, but serum 25-OHD(3) level was weakly correlated with spine BMD, which may have physiological importance and public health consequences.
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Faculty Member's Name: Siamak Arami, MD
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