Materials and methods of research: 380 women with primary hypothyrosis were examined (96 patients with decompensated hypothyrosis (1-st group) and 165 patients with compensated L-thyroxinus on the background of autoimmune thyreoiditus and endemic goiter (2-nd group) and also 119 patients with postoperation compensated hypothyrosis (3-rd group) and 100 patients without thyroid disease (control group). All the women have menopause for 2 to 17 years. Level of bone resorption marker-carboxy-terminal telopeptide (CTx) of type I collagen was defined in the second portion of the morning urine by immunity fermental method using test-systems CrossLaps TM ELISA of the firm «Osteometer Bio Tech». In blood serum on an empty stomach the level of bone formation marker – bone alkaline phosphatase (BAP) was tested (sets of the «Abbott» firm (USA)) as well as the indicator of bone circulation speed – serum osteocalcine (OC) (Cis Bio international (France). Results: Patients of groups 1 and 2 have no distinctions with the patients of control group in the indices of BAP activity. The patients of group 3 had the growth of BAP index in comparison with healthy women. It means the intensification of bone formation processes of the given contingent of patients. Tendency of growth and intensification of general excretion of CTx in urine in comparison with women without thyreoid pathology was the feature of patients with decompensated hypothyrosis as with compensated one. The most intensive excretion of Ctx was the feature of group 3 patients whose CTx concentration was 2,5 times move. The growth of OC was the characteristic of all the patients with primary hypothyrosis irrespective of its compensation level. It testifies to intensification of bone circulation speed in post – menopause of these patients. Conclusions: Thus, hypothyrosis (especially post-operation and compensated by L-thyroxin) in post – menopause in a region with iodine deficiency promotes the growth of bone metabolism level. So, timely antiresorbtive therapy is reguired for the given contingent of patients to prevent the symptoms of osteoporosis.
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Faculty Member's Name: Asya E. Esedova, Assistant
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