Leptin is significantly broadening our understanding of mechanisms underlying bone metabolism in general and osteoporosis in particular. Leptin, an adipocyte derived multifunctional hormone has been implicated in understanding the effect of estrogen and hormonal deficiencies on bone and to orchestrate complex ongoing pathophysiological processes leading to osteoporosis. It has been shown to act on immortalized bone marrow stromal cells to enhance differentiation to osteoblast suggesting a favorable effect of leptin on bone mineral density(BMD). Since little is known about the relationship between leptin and bone mass, we studied a correlation between leptin, a specific bone resorption marker (CTX) and BMD in postmenopausal osteoporotic Indian women and also studied the effect of interventional therapies on these parameters . Sixty postmenopausal osteoporotic women with T scores above –2.5 were recruited for this study .They were put on three modes of treatment ,Bisphosphonate ,Calcium and HRT with 20 subjects in each group. Serum Leptin and Urinary CTX were estimated at 0,3,6 and 12 month post treatment. BMD was done at 0 and 12 months post treatment. Baseline CTX values were significantly high suggesting high bone resorption rate while BMD scores and serum leptin values were in the lower range. A significant decrease in CTX value ranging 50-70% of baseline was observed at 3 months posttreatment in all three groups while leptin increased to more than 50%. 6 months post treatment no significant change was observed in CTX value while leptin increased up to 70% of baseline in all the groups. At 12 months of post treatment, CTX levels were within the normal range with increase in BMD scores while leptin levels plateaued. Bisphosphonate gave better results in terms of lowering bone resorption rate and increase in BMD scores and leptin levels .The results of this study show that leptin is directly proportional to BMD and inversely to CTX which supports the hypothesis that leptin plays an important protective role in bone metabolism by inhibiting bone resorption.
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Faculty Member's Name: VIPLA C. PURI Sr., PHD
I have no relationships to disclose.
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